The long wait for football is over. The NFL season has arrived. For Arizona sports betting fans, the hope is that this is the season that their beloved Arizona Cardinals put it all together and make it back to the Super Bowl. Could they even go on to claim their first championship? That quest will be starting in earnest on September 11th, 2022. Who do the Cardinals play in Week 1?

Who Do The Cardinals Play In Week 1?

For Week 1, the Arizona Cardinals will be hosting the Kansas City Chiefs. The two teams will meet at State Farm Stadium in Phoenix, AZ, The game will start at 4:25 PM ET.

The betting line on the game is Kansas City -4.5, and the over/under is 53.5.

What a way to start the 2022 season. This game pits what could well be the two best offenses in the NFL against each other. Both teams are entering this season with the highest of hopes, willing to accept nothing less than a trip to the Super Bowl.

Chiefs vs Cardinals – Loaded Offenses

The Cardinals are led by QB Kyler Murray, a dual threat who seems on the cusp of superstardom. The offense is loaded with a great supporting cast that includes RB James Conner (18 TDs last year), WR Marquise Brown (1,006 yds receiving, 6 TDS. and the ageless wonder WR A.J. Green.

The Chiefs hopes always ride on the leadership of former NFL MVP QB Patrick Mahomes. The real challenge he faces this year is synchronizing the offense with a lot of new pieces in the fold. Mahomes loses his favorite target Tyreek Hill but picks up a couple of good young receivers in Marquez Valdes-Scantling and JuJu Smith-Schuster.

This is a game that will also attract a lot of attention for Kansas sports betting, the newest state to legalize online betting.

Game Prediction:

The Chiefs are favored on the road against a Cardinals team that can always put points on the board. Thinking the Chiefs offense might need a game or two to reach optimum efficiency, the Cardinals look like the right side, perhaps an outright win is on the cards.

Score Prediction: Cardinals 31 Chiefs 23.